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. 2021 Jan 7;217(3):iyaa041. doi: 10.1093/genetics/iyaa041

Table 1.

Statistical properties of different methods as applied to the analysis of data generated according to the model (15)

n Model Power1 Power2 Power3 FP FDR
200 fixed 0.86 0.92 0.06 4.38 0.69
[2.99, 0.18] [3.26, 0.30] [3.83, 0.08]
fixed 0.88 0.85 0.26 3.67 0.63
PC = 3 [2.55, 0.13] [2.95, 0.24] [2.80, 0.10]
fixed 0.91 0.56 0.46 0.5 0.17
PC = 10 [1.49, 0.09] [1.86, 0.13] [1.92, 0.13]
mixed 0.89 0.78 0.78 0.04 0.01
μ0 [1.13, 0.06] [1.92, 0.08] [1.99, 0.08]
mixed 0.71 0.52 0.04 0.01 0.00
μ = 0 [0.46, 0.05] [0.87, 0.06] [0.85, 0.06]
mixed 0.71 0.45 0.10 0.02 0.01
PC = 3 [1.14, 0.12] [1.60, 0.22] [1.10, 0.17]
mix 0.77 0.34 0.28 0.04 0.02
PC = 10 [1.17, 0.09] [1.40, 0.17] [1.28, 0.17]
400 fixed 1 1 0.36 11.0 0.81
[2.62, 0.12] [1.91, 0.23] [1.53, 0.18]
fixed 0.99 0.95 0.57 6.73 0.71
PC = 3 [1.49, 0.10] [1.65, 0.17] [1.31, 0.12]
fixed 1.00 0.92 0.93 0.83 0.19
PC = 10 [0.68, 0.07] [1.06, 0.08] [1.00, 0.08]
mixed 0.99 0.98 0.98 0.05 0.01
μ0 [0.46, 0.05] [0.87, 0.06] [0.85, 0.06]
mixed 0.98 0.86 0.26 0.01 0.00
μ = 0 [0.52, 0.08] [0.86, 0.12] [0.54, 0.04]
mixed 0.98 0.80 0.41 0.02 0.01
PC = 3 [0.50, 0.07] [0.84, 0.11] [0.67, 0.6]
mixed 0.99 0.81 0.82 0.06 0.02
PC = 10 [0.51, 0.07] [0.79, 0.07] [0.77, 0.07]

We report Power, average number of false positives (FP) and false discovery rate (FDR). The square brackets report a mean distance to a simulated QTL and a mean value of |β^iβi|. A fixed effects model and a mixed model with μ = 0 are additionally supplemented with the first 3 or 10 PCs of the incidence matrix X.