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. 2021 Jan 7;217(3):iyaa041. doi: 10.1093/genetics/iyaa041

Table 2.

Statistical properties of different methods as applied to the analysis of data generated according to the model (15) when the markers are spaced every 5 cM.

n Model Power1 Power2 Power3 FP FDR
200 fixed 0.92 0.94 0.11 6.58 0.76
[2.68,0.16] [4.04,0.27] [3.67,0.13]
fixed 0.93 0.85 0.31 4.52 0.66
PC = 3 [2.07,0.12] [3.83,0.2] [3.51,0.1]
fixed 0.92 0.55 0.48 0.74 0.24
PC = 10 [0.93,0.09] [3.22,0.1] [3.17,0.09]
mixed 0.91 0.80 0.80 0.08 0.02
μ0 [0.67,0.06] [3.17,0.07] [3.29,0.07]
mixed 0.59 0.37 0.01 0.004 0.002
μ = 0 [0.59,0.12] [2.95,0.19] [2.46,0.11]
mixed 0.64 0.37 0.07 0.03 0.02
PC = 3 [0.72,0.11] [3.03,0.18] [2.96,0.13]
mixed 0.73 0.29 0.23 0.07 0.03
PC = 10 [0.72,0.09] [2.86,0.13] [2.83,0.13]
400 fixed 1 0.99 0.39 11.98 0.82
[1.63,0.12] [3.37,0.18] [2.94,0.19]
fixed 0.999 0.95 0.59 7.70 0.73
PC = 3 [1,0.1] [3.16,0.14] [2.77,0.12]
fixed 1 0.89 0.90 1.03 0.23
PC = 10 [0.41,0.07] [2.7,0.08] [2.68,0.08]
mixed 0.999 0.98 0.98 0.10 0.02
μ0 [0.17,0.06] [2.61,0.07] [2.68,0.06]
mixed 0.93 0.65 0.07 0.006 0.002
μ = 0 [0.14,0.07] [2.51,0.08] [2.32,0.04]
mixed 0.95 0.65 0.24 0.03 0.008
PC = 3 [0.13,0.07] [2.59,0.08] [2.43,0.05]
mixed 0.98 0.66 0.68 0.08 0.02
PC = 10 [0.14,0.06] [2.47,0.06] [2.54,0.06]

We report Power, average number of false positives (FP) and false discovery rate (FDR). The square brackets report a mean distance to a simulated QTL and a mean value of |β^iβi|. A fixed effects model and a mixed model with μ = 0 are additionally supplemented with the first 3 or 10 PCs of the incidence matrix X. The polygenic effects are uniformly distributed at the distance of 1 cM but the search is performed over markers spaced 5 cM.