Table 2.
n | Model | Power1 | Power2 | Power3 | FP | FDR |
---|---|---|---|---|---|---|
200 | fixed | 0.92 | 0.94 | 0.11 | 6.58 | 0.76 |
[2.68,0.16] | [4.04,0.27] | [3.67,0.13] | ||||
fixed | 0.93 | 0.85 | 0.31 | 4.52 | 0.66 | |
PC = 3 | [2.07,0.12] | [3.83,0.2] | [3.51,0.1] | |||
fixed | 0.92 | 0.55 | 0.48 | 0.74 | 0.24 | |
PC = 10 | [0.93,0.09] | [3.22,0.1] | [3.17,0.09] | |||
mixed | 0.91 | 0.80 | 0.80 | 0.08 | 0.02 | |
[0.67,0.06] | [3.17,0.07] | [3.29,0.07] | ||||
mixed | 0.59 | 0.37 | 0.01 | 0.004 | 0.002 | |
μ = 0 | [0.59,0.12] | [2.95,0.19] | [2.46,0.11] | |||
mixed | 0.64 | 0.37 | 0.07 | 0.03 | 0.02 | |
PC = 3 | [0.72,0.11] | [3.03,0.18] | [2.96,0.13] | |||
mixed | 0.73 | 0.29 | 0.23 | 0.07 | 0.03 | |
PC = 10 | [0.72,0.09] | [2.86,0.13] | [2.83,0.13] | |||
400 | fixed | 1 | 0.99 | 0.39 | 11.98 | 0.82 |
[1.63,0.12] | [3.37,0.18] | [2.94,0.19] | ||||
fixed | 0.999 | 0.95 | 0.59 | 7.70 | 0.73 | |
PC = 3 | [1,0.1] | [3.16,0.14] | [2.77,0.12] | |||
fixed | 1 | 0.89 | 0.90 | 1.03 | 0.23 | |
PC = 10 | [0.41,0.07] | [2.7,0.08] | [2.68,0.08] | |||
mixed | 0.999 | 0.98 | 0.98 | 0.10 | 0.02 | |
[0.17,0.06] | [2.61,0.07] | [2.68,0.06] | ||||
mixed | 0.93 | 0.65 | 0.07 | 0.006 | 0.002 | |
μ = 0 | [0.14,0.07] | [2.51,0.08] | [2.32,0.04] | |||
mixed | 0.95 | 0.65 | 0.24 | 0.03 | 0.008 | |
PC = 3 | [0.13,0.07] | [2.59,0.08] | [2.43,0.05] | |||
mixed | 0.98 | 0.66 | 0.68 | 0.08 | 0.02 | |
PC = 10 | [0.14,0.06] | [2.47,0.06] | [2.54,0.06] |
We report Power, average number of false positives (FP) and false discovery rate (FDR). The square brackets report a mean distance to a simulated QTL and a mean value of . A fixed effects model and a mixed model with μ = 0 are additionally supplemented with the first 3 or 10 PCs of the incidence matrix X. The polygenic effects are uniformly distributed at the distance of 1 cM but the search is performed over markers spaced 5 cM.