Table 1.
Summary of AI profiles identified across 33 tumor sites in TCGA
| Tumor site | TCGA abbreviation | Number of samples | Number of samples with AI | Samples with AI (%) | Genomic burden (median) |
|---|---|---|---|---|---|
| Adrenocortical carcinoma | ACC | 90 | 90 | 100.00 | 0.6326 |
| Bladder urothelial carcinoma | BLCA | 411 | 408 | 99.27 | 0.5300 |
| Breast invasive carcinoma | BRCA | 1101 | 1093 | 99.27 | 0.4366 |
| Cervical squamous cell carcinoma and endocervical adenocarcinoma | CESC | 303 | 301 | 99.34 | 0.3444 |
| Cholangiocarcinoma | CHOL | 36 | 34 | 94.44 | 0.3842 |
| Colon adenocarcinoma | COAD | 462 | 455 | 98.48 | 0.3656 |
| Lymphoid neoplasm diffuse large B-cell lymphoma | DLBC | 48 | 47 | 97.92 | 0.2011 |
| Esophageal carcinoma | ESCA | 186 | 184 | 98.92 | 0.6446 |
| Glioblastoma multiforme | GBM | 545 | 539 | 98.90 | 0.2088 |
| Head and neck squamous cell carcinoma | HNSC | 527 | 526 | 99.81 | 0.4324 |
| Kidney chromophobe | KICH | 66 | 64 | 96.97 | 0.4115 |
| Kidney renal clear cell carcinoma | KIRC | 529 | 521 | 98.49 | 0.1731 |
| Kidney renal papillary cell carcinoma | KIRP | 288 | 281 | 97.57 | 0.1996 |
| Acute myeloid leukemia | LAML | 200 | 106 | 53.00 | 0.0014 |
| Brain lower grade glioma | LGG | 527 | 517 | 98.10 | 0.1317 |
| Liver hepatocellular carcinoma | LIHC | 377 | 369 | 97.88 | 0.3194 |
| Lung adenocarcinoma | LUAD | 517 | 514 | 99.42 | 0.5539 |
| Lung squamous cell carcinoma | LUSC | 502 | 495 | 98.61 | 0.5921 |
| Mesothelioma | MESO | 87 | 85 | 97.70 | 0.2800 |
| Ovarian serous cystadenocarcinoma | OV | 595 | 592 | 99.50 | 0.6202 |
| Pancreatic adenocarcinoma | PAAD | 185 | 170 | 91.89 | 0.2627 |
| Pheochromocytoma and paraganglioma | PCPG | 183 | 179 | 97.81 | 0.1543 |
| Prostate adenocarcinoma | PRAD | 496 | 465 | 93.75 | 0.0910 |
| Rectum adenocarcinoma | READ | 168 | 167 | 99.40 | 0.5100 |
| Sarcoma | SARC | 261 | 253 | 96.93 | 0.4069 |
| Skin cutaneous melanoma | SKCM | 472 | 469 | 99.36 | 0.4263 |
| Stomach adenocarcinoma | STAD | 442 | 436 | 98.64 | 0.4303 |
| Testicular germ cell tumors | TGCT | 156 | 156 | 100.00 | 0.6504 |
| Thyroid carcinoma | THCA | 509 | 195 | 38.31 | 0.0000 |
| Thymoma | THYM | 124 | 85 | 68.55 | 0.0263 |
| Uterine corpus endometrial carcinoma | UCEC | 546 | 481 | 88.10 | 0.1174 |
| Uterine carcinosarcoma | UCS | 55 | 55 | 100.00 | 0.5941 |
| Uveal melanoma | UVM | 80 | 79 | 98.75 | 0.1628 |