Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Mar 31;11:635233. doi: 10.3389/fonc.2021.635233

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Guo, Ma, Fu, Liu, Liu, Hu, Miao, Zhang, Liu, Han, You, Yang and Zheng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Systematical diagram of design idea and researching flow of discovering a dominant negative mutant derived from survivin with stronger pro-apoptotic activity to cancer. (A) Compared with TmSm34, TmSm48, TmSm84, TmSm34/48, and TmSm34/48/84, TmSm34/84 had the strongest capacity in inhibiting proliferation and promoting apoptosis of A549 cells. (B) TmSm34/84 could reverse the drug resistance of A549 CSCs to Adriamycin (ADM) by down-regulating survivin, Bcl-2, and P-gp expression, while up-regulating cleaved caspase-3 expression.