Figure 3.
Pneumococcal transmission with or without CSE. (A) Pneumococcal colonization of index and contact mice in the index and contact-CSE group (index and contact received CSE) (n = 14) and the control group (index and contact received PBS) (n = 11). (B) Pneumococcal colonization of index and contact mice of index-CSE group (n = 8) and the contact-CSE group (n = 8) transmission studies. Each symbol represents the colonization density in nasal lavages for individual pups (CFU/ml), with median values indicated by a bar. CSE group (circles), PBS group (square); index mice (closed symbols), contact mice (open symbols). Dotted line indicates the limit of detection (666 CFU/ml). Mann-Whitney U test was used for the statistical analyses.