Table 3.

Association of Traditional CV Risk Factors With Incident Site Specific Cancer Subtypes

	GI Cancer (n/N = 514/20,305)		Lung Cancer (n/N = 287/20,305)		Prostate Cancer (n/N = 397/9,426)		Breast Cancer (n/N = 449/10,879)
	HR (95% CI)	p Value	HR (95% CI)	p Value	HR (95% CI)	p Value	HR (95% CI)	p Value
Age	2.48 (2.17−2.85)	<0.001	2.92 (2.41−3.52)	<0.001	2.77 (2.37−3.24)	<0.001	1.32 (1.14−1.53)	<0.001
Male	1.91 (1.58−2.30)	<0.001	1.70 (1.33−2.18)	<0.001	—	—	—	—
SBP	0.96 (0.87−1.05)	0.36	1.02 (0.90−1.15)	0.75	1.00 (0.90−1.12)	0.94	1.06 (0.95−1.17)	0.30
HTN treatment	1.11 (0.90−1.38)	0.33	1.24 (0.93−1.65)	0.14	1.01 (0.79−1.30)	0.92	1.17 (0.91−1.51)	0.21
BMI	1.14 (1.03−1.26)	0.008	0.77 (0.67−0.90)	0.001	1.02 (0.89−1.16)	0.82	1.01 (0.99−1.03)	0.43
DM	1.63 (1.20−2.21)	0.002	0.97 (0.58−1.60)	0.89	0.73 (0.48−1.12)	0.15	0.88 (0.54−1.44)	0.61
Former smoker	1.36 (1.09−1.69)	0.006	3.90 (2.45−6.20)	<0.001	0.93 (0.73−1.17)	0.52	1.08 (0.86−1.35)	0.51
Current smoker	1.75 (1.37−2.22)	<0.001	13.0 (8.24−20.6)	<0.001	0.79 (0.59−1.06)	0.12	1.32 (1.04−1.66)	0.021
TC/HDL	0.86 (0.77−0.95)	0.004	1.07 (0.99−1.16)	0.08	0.97 (0.87−1.08)	0.53	0.97 (0.86−1.10)	0.62
Statin use	1.13 (0.78−1.63)	0.51	0.99 (0.59−1.66)	0.97	0.66 (0.41−1.08)	0.10	0.79 (0.48−1.31)	0.36

Multivariable model adjusts for age, sex, SBP, HTN treatment, BMI, DM, TC/HDL, statin use, smoking status. HR: per dichotomous variable or 1 SD increase in continuous variables.

GI = gastrointestinal; other abbreviations as in Tables 1 and 2.