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. 2021 Mar 11;8(4):877–886. doi: 10.1002/acn3.51338

Figure 2.

Figure 2

Distribution of myeloid cells in rim+ and rim− lesions. A representative rim+ lesion with (A) loss of myelin in the lesion center contains (B) a high density of myeloid cells at the lesion rim and (C) Perls+ cells with an activated morphology. A representative rim− lesion with (D) complete loss of myelin contains (E) a thin layer of myeloid cells at the lesion rim but (F) lacks Perls+ cells. (G–H) Histological quantification. (I) Myeloid cells extend further into the NAWM of iron+ lesions as compared to iron− lesions. Bars represent mean + SEM of n > 10 ROIs. Average linear density in Center, Rim, NAWM were compared between iron+ and iron− lesions to determine statistical significance. MBP, myelin basic protein; *p < 0.05; **p < 0.01; ***p < 0.001.