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. 2021 Mar 12;20(4):e13338. doi: 10.1111/acel.13338

FIGURE 2.

FIGURE 2

Phenotypical changes observed within aging cells. With progression of cellular aging, cells experience a gradual transition from the balanced state of coordinated growth and proliferation, to the state where soma growth dominates over proliferation. That occurs in parallel to metabolic shifts, reduction in NAD+, intracellular damage accumulation, and telomere shortening