Figure 6. PCaA-SEV promotes T cell recruitment to the tumor microenvironment.

Mice were immunized with PCaA-SEV, 3 times at 2-week intervals and challenged with TRAMP-C2. Three weeks after tumor inoculation, a paracentesis was performed for analysis of leukocyte subsets by flow cytometry. (A) Flow cytometric representation of CD8⁺ T cells from the total CD3⁺ and CD44⁺ cells. (B) Enhanced infiltration of anti-tumor CD8⁺ T cells in the tumor microenvironment of mice vaccinated with PCaA-SEV, after inoculation with TRAMP-C2 prostate tumors for 3 weeks.