Table 3.
Changes in body compositions, blood pressure and hand grip strength after 12 weeks of treatment with dapagliflozin vs teneligliptin
| Dapagliptin group (n = 12) |
Teneligliptin group (n = 10) |
Difference (95% CI) | ||||
|---|---|---|---|---|---|---|
| Baseline | Post-treatment | Baseline | Post-treatment | |||
| Body compositions | ||||||
| Body weight (kg) | 76.5 (20.7) | 75.2 (20.9)* | 78.4 (15.1) | 78.4 (15.0) | 1.4 (–0.0, 2.9) | |
| BMI (kg/m2) | 27.9 (4.3) | 27.4 (4.3)* | 28.7 (4.4) | 28.7 (4.5) | 0.5 (0.1, 1.1)*** | |
| Waist circumference (cm) | 95.0 (10.7) | 94.3 (10.7) | 94.9 (9.6) | 95.2 (10.6) | 1.0 (–0.4, 2.4) | |
| Total body water (L) | 37.9 (11.0) | 37.2 (11.1)* | 37.4 (7.5) | 37.5 (7.6) | 0.74 (0.03, 1.45)*** | |
| Protein (kg) | 10.2 (3.1) | 10.0 (3.1)* | 9.8 (2.2) | 9.8 (2.2) | 0.19 (–0.01, 0.39) | |
| Mineral (kg) | 3.48 (1.04) | 3.42 (1.03)** | 3.45 (0.70) | 3.44 (0.71) | 0.05 (–0.01, 0.10) | |
| Body fat mass (kg) | 24.9 (8.1) | 24.5 (8.2) | 28.0 (8.8) | 28.2 (8.9) | 0.6 (–0.4, 1.6) | |
| Percent body fat (%) | 32.8 (7.2) | 32.8 (7.4) | 35.2 (6.0) | 35.3 (6.2) | 0.1 (–0.7, 1.0) | |
| Skeletal muscle mass (kg) | 28.7 (9.2) | 28.3 (9.2)* | 28.4 (6.3) | 28.4 (6.3) | 0.4 (–0.1, 1.0) | |
| Percent skeletal muscle (%) | 37.3 (4.8) | 37.3 (4.9) | 36.0 (3.8) | 36.0 (3.9) | 0.1 (–0.3, 0.6) | |
| Blood pressure | ||||||
| Systolic blood pressure (mmHg) | 126.1 (10.7) | 121.8 (8.6) | 121.8 (10.4) | 118.7 (8.6) | 1.2 (–5.2, 7.7) | |
| Diastolic blood pressure (mmHg) | 76.2 (7.1) | 74.7 (9.2) | 73.6 (3.8) | 71.8 (4.3) | 1.1 (–3.3, 5.6) | |
| Hand grip strength | ||||||
| Right hand grip strength (kg) | 35.8 (14.1) | 37.5 (13.2)* | 36.8 (9.6) | 38.1 (15.8) | 0.4 (–2.7, 3.4) | |
| Left hand grip strength (kg) | 32.9 (14.0) | 33.8 (12.5) | 33.9 (13.0) | 35.0 (13.7) | 0.3 (–2.0, 2.5) | |
Values are expressed as the mean ± SD; *p<0.05 vs baseline; **p<0.01 vs baseline; ***p<0.05 vs teneligliptin.