Table 1.

Multi-functional role of heparanase in myeloma progression

Impact	References
Promotes myeloma growth, proliferation and metastasis	[8] [54] [53] [44] [45] [61] [11] [14]
Promotes osteolysis	[54] [52]
Enhance endothelial cell invasion and angiogenesis	[56] [45] [8]
Promotes exosome biogenesis and exosome docking	[66, 71] [67]
Promotes syndecan-1 shedding and myeloma cell migration	[4] [8]
Regulates signaling and gene transcription	[22] [45]
Promotes drug resistance	[74] [13] [69]