. 2021 Jan 15;42(7):2032–2044. doi: 10.1002/hbm.25343

TABLE 2.

Areas of increased and decreased connectivity for main effect of group (VSS patients vs. Ctrl), at rest and during the visual task, from selected ROIs to the rest of the brain

ROI	Condition	Contrast	Brain regions and Brodmann areas	Mean beta values		P (FWE)	P (FDR)	k	T	Peak coordinates
ROI	Condition	Contrast	Brain regions and Brodmann areas	VSS	Ctrl	P (FWE)		k	T	x	y	z
Pv	Rest	VSS > Ctrl	R SMG and postcentral gyrus (BA 1,3)	−0.01	−0.18	.05	.05	382	4.32	50	−20	46
		VSS < Ctrl	Bilateral caudate nuclei ^a	0.09	0.27	≤ .001	.01	967	4.68	−12	−6	16
	Task	VSS > Ctrl	R LG (BA 19) ^a	0.22	0.02	.04	.04	410	4.27	26	−54	−2
V1	Rest	VSS > Ctrl	L SMG and postcentral gyrus (BA 1,3) ^b	−0.03	−0.22	.05	.05	346	4.54	−64	−20	32
	Task	VSS > Ctrl	R IOG (area V5, BA 18,19) ^b	0.24	0.01	.05	.05	332	5.02	52	−64	6
			R SMG and postcentral gyrus (BA 1,3) ^b	0.00	−0.19	.007	.03	572	4.68	58	−24	40
			R precentral gyrus (BA 8, 6, FEF) ^a	0.08	−0.13	.003	.02	696	4.53	52	10	28
V5	Rest	VSS < Ctrl	PCC, L/R medial precuneus (BA 7) ^b	−0.13	0.11	.01	.04	554	4.46	−6	−52	42
	Task	VSS > Ctrl	Bilateral MOG, SOG, IOG, FG, (BA 17, 18, 19, V1‐V3), SMG, cuneus ^b	0.65	0.37	≤ .001	.01	5,598	5.71	38	−84	10
			R SPL/intraparietal sulcus (BA 7, BA5) ^b	0.53	0.27	≤ .001	.01	936	5.0	26	−60	60
			R precentral gyrus (BA 8, 6, FEF) ^b	0.41	0.16	.02	.04	420	4.25	48	2	38
		VSS < Ctrl	PCC, bilateral medial precuneus ^b	−0.25	0.00	≤ .001	.01	6,838	6.16	−4	−52	52
			R TPJ and AG (BA 39, BA 40) ^b	−0.17	0.05	≤ .001	.01	928	5.12	44	−56	28
PCu	Rest	VSS > Ctrl	R precentral gyrus (BA 8, 6, FEF)	0.38	−0.17	.004	.03	337	4.37	48	4	36
PCC/pMCC	Task	VSS > Ctrl	PCC, bilateral medial precuneus ^b	0.28	0.05	≤ .001	.01	1,535	4.12	−4	−50	58
Cb	Rest	VSS < Ctrl	PCC, bilateral medial precuneus	−0.17	0.01	.007	0.03	605	4.44	−10	−50	38
	Task	VSS > Ctrl	R SPL/lateral precuneus, postcentral gyrus (BA 2, 1,3)	0.05	−0.16	.004	.03	685	4.24	36	−40	72

Note: Clusters are shown in coordinate MNI space with relative T scores and k values. An initial voxel threshold of P < .001 and cluster correction to P < .05 was applied. Adjusted P thresholds following FDR correction for multiple testing are also shown; all clusters survived correction. Mean beta values for the clusters are shown for VSS and Ctrls. a and b indicate clusters that survived significance in a post hoc analysis run with migraine presence as a covariate.

Abbreviations: AG, angular gyrus; BA, Brodmann area; Cb, left cerebellum lobule VI; FEF, frontal eye field; FG, fusiform gyrus; IOG, inferior occipital gyrus; L, left; LG, lingual gyrus; MOG, middle occipital gyrus; PCC, posterior cingulate cortex; PCC, posterior cingulate cortex; PCu, left precuneus; pMCC, posterior mid‐cingulate cortex; Pv, right pulvinar; R, right; SMA, supplementary motor area; SMG, supramarginal gyrus; SOG, superior occipital gyrus; SPL, superior parietal lobule; TPJ, temporoparietal junction; V1, right primary visual area; V5, right V5 area.

^{^a}

Cluster present in post hoc analysis covarying for migraine presence, with reduced cluster forming threshold of P = .005.

^{^b}

Cluster present in post hoc analysis covarying for migraine presence.