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. 2021 Feb 2;10(5):681–693. doi: 10.1002/sctm.20-0361

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© 2021 The Authors. stem cells translational medicine published by Wiley Periodicals LLC on behalf of AlphaMed Press

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Sources and potential applications of neural crest stem cells (NCSCs) and neural crest‐like stem cells (NCLSCs). NCSCs and NCLSCs can be isolated from embryonic, fetal, placental, and adult tissues. NCLSCs can also be derived in vitro from pluripotent stem cells and mature cells through differentiation and reprogramming strategies, respectively. NCSCs and NCLSCs can be differentiated to yield distinct cell derivatives that are highly valuable for tissue engineering applications and disease modeling