TABLE 2.

Immune‐induced pulmonary toxicities by common terminology criteria for adverse events (CTCAE) grade (v5.0), with suggested management by Delaunay et al. ⁴

CTCAE grade 5.0	Definition	Suggested management
Grade 1	Asymptomatic	Continuation of IT, monitoring
Grade 2	Symptomatic, limiting instrumental ADL and requiring medical intervention	Stop IT, oral corticosteroids 0,5–1 mg/kg, monitoring, potential rechallenge
Grade 3	Severe symptoms, limiting self‐care ADL and indicated oxygen	Stop IT, oral corticosteroids 2–4 mg/kg, no rechallenge, monitoring
Grade 4	Life‐threatening respiratory compromise and indicated urgent intervention	Stop IT, intravenous corticosteroids 4 mg/kg, no rechallenge, monitoring

Abbreviations: ADL, activities of daily living; IT, immunotherapy.