Table 2.
Serum Leptin Level and LEPR Gln223Arg Genotypes in Relation to Clinicopathological Features of Patients with HCC
| Serum Leptin (ng/ml) | P value | LEPR Gln223Arg (No. of Genotypes) |
P-value | |||
|---|---|---|---|---|---|---|
| GG | GA | AA | ||||
| Age | ||||||
| <50 | 4.4±1.2 | <0.05* | 5 | 5 | 0 | <0.05* |
| >50 | 6.6±0.37 | 55 | 30 | 5 | ||
| Sex | ||||||
| Male | 6.4±0.39 | N.S | 45 | 25 | 5 | N.S |
| Female | 6.2±1.1 | 15 | 10 | 0 | ||
| AFP(ng/ml) | ||||||
| <200 | 6.6±0.46 | N.S | 25 | 30 | 5 | <0.05 |
| >200 | 5.9±0.69 | 35 | 5 | 0 | ||
| Tumor size | <0.05 | 0.05 | ||||
| <5 cm | 7.1±0.34 | 25 | 30 | 5 | ||
| >5 cm | 5.5±0.66 | 35 | 5 | 0 | ||
| TNM | ||||||
| I, II | 6.6±0.51 | N.S | 5 | 20 | 25 | N.S |
| III | 5.9±0.59 | 40 | 10 | 0 | ||
| Tumor grade | ||||||
| Well, diff. | 7.0±0.4 | N.S | 35 | 15 | 0 | N.S |
| Moderate – poor diff. | 6.0±0.53 | 25 | 20 | 5 | ||
| Child-Pugh Class | 0.05 | |||||
| A | 6.9±0.39 | N.S | 30 | 5 | 0 | |
| B+C | 5.5±0.7 | 30 | 30 | 5 | ||