Table 5.
Univariate and Multivariate Analysis of Factors Associated with Severe Adverse Events of Febrile Neutropenia
| Univariate |
Multivariate |
|||||
|---|---|---|---|---|---|---|
| Variables | Odds ratio | 95% CI | P-value | Adjusted Odds ratio | 95% CI | P-value |
| Type of malignancy | ||||||
| ALL, High risk | 1.11 | (0.68 to 1.79) | 0.646 | 0.78 | (0.41 to 1.48) | 0.448 |
| ALL, Standard risk | 0.44 | (0.18 to 0.96) | 0.032 | 0.47 | (0.19 to 1.2) | 0.114 |
| AML | 1.86 | (1.16 to 2.95) | 0.006 | 0.92 | (0.49 to 1.74) | 0.809 |
| High risk group | 4.15 | (2.08 to 9.19) | <0.001 | 3.35 | (1.56 to 7.17) | 0.002 |
| Treatment not according to CPG | 2.07 | (1.33 to 3.22) | 0.001 | 2.47 | (1.51 to 4.03) | <0.001 |
| Chemotherapy – Induction for leukemia | 1.79 | (1.13 to 2.82) | 0.008 | 1.02 | (0.59 to 1.75) | 0.945 |
| Central venous catheter use | 5.53 | (3.44 to 8.99) | <0.001 | 4.28 | (2.51 to 7.29) | <0.001 |
| Type of pathogen | ||||||
| Bacteria | 1.86 | (1.16 to 2.94) | 0.006 | 1.66 | (0.98 to 2.79) | 0.058 |
| Virus | 2.04 | (0.82 to 4.72) | 0.072 | 2.72 | (1.05 to 7.06) | 0.04 |
| Fungus | 7.88 | (3.16 to 20.76) | <0.001 | 6.51 | (2.29 to 18.56) | <0.001 |
| Lower respiratory tract infection | 5.34 | (2.58 to 11.04) | <0.001 | 2.52 | (1.09 to 5.82) | 0.031 |
ALL, Acute lymphoblastic leukemia; AML, Acute lymphoblastic leukemia