Table 3.

Univariate Analysis for Overall Survival Comparing Different Sites of Metastasis in Different Subtypes

Metastatic Site	HR+/HER2-		HR+/HER2+		HR-/HER2+		TNBC
	Hazard Ratio (95% CI)	P	Hazard Ratio (95% CI)	P	Hazard Ratio (95% CI)	P	Hazard Ratio (95% CI)	P
Bone vs. Brain	0.35 (0.21-0.60)	<0.0001*	1.55 (0.21-11.17)	0.333	0.43 (0.21-0.90)	0.012*	0.62 (0.41-0.92)	0.009*
Bone vs. Liver	0.82 (0.64-1.05)	0.055	0.80 (0.50-1.28)	0.178	1.23 (0.77-1.95)	0.191	0.74 (0.57-0.96)	0.011*
Bone vs. Lung	0.91 (0.75-1.11)	0.18	0.78 (0.43-1.40)	0.203	0.82 (0.51-1.34)	0.217	0.90 (0.73-1.11)	0.154
Bone vs. Multiple	0.44 (0.38-0.50)	<0.0001*	0.41 (0.28-0.61)	<0.0001*	0.50 (0.33-0.76)	0.001*	0.49 (0.40-0.61)	<0.0001*
Brain vs. Liver	2.32 (1.31-4.12)	0.002*	0.52 (0.07-3.83)	0.26	2.85 (1.37-5.92)	0.003*	1.20 (0.78-1.84)	0.203
Brain vs. Lung	2.58 (1.48-4.50)	0.0004*	0.51 (0.07-3.84)	0.255	1.91 (0.90-4.02)	0.045*	1.46 (0.98-2.17)	0.032*
Brain vs. Multiple	1.24 (0.72-2.11)	0.219	0.27 (0.04-1.94)	0.096	1.16 (0.57-2.33)	0.341	0.80 (0.54-1.19)	0.131
Liver vs. Lung	1.11 (0.83-1.50)	0.241	0.98 (0.51-1.88)	0.47	0.67 (0.41-1.09)	0.053	1.22 (0.94-1.57)	0.066
Liver vs. Multiple	0.53 (0.41-0.69)	<0.0001*	0.52 (0.32-0.84)	0.004*	0.41 (0.27-0.62)	<0.0001*	0.67 (0.51-0.86)	0.001*
Lung vs. Multiple	0.48 (0.39-0.59)	<0.0001*	0.53 (0.29-0.96)	0.018*	0.61 (0.39-0.94)	0.013*	0.55 (0.45-0.67)	<0.0001*

* Significant P value (<0.05)