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. Author manuscript; available in PMC: 2021 Apr 14.
Published in final edited form as: Cell Rep. 2020 Jul 7;32(1):107872. doi: 10.1016/j.celrep.2020.107872

Figure 2. Acute IL-13 Stimulation Drives Cellular Remodeling of the Mucociliary Epithelium.

Figure 2.

(A) Schematic detailing human AEC ALI mucociliary differentiation followed by acute stimulation with IL-13; n = 2 human tracheal epithelial cell (HTEC) donors (T71, T72).

(B) t-SNE plot of 1,894 cells depicting nine unsupervised scRNA-seq clusters.

(C) t-SNE plot in (B), with cells colored by characteristic expression of ciliated, secretory, or basal cell gene signatures. See also Figures S1C–S1E.

(D) t-SNE plot in (B), with cells colored by treatment.

(E) Pie charts of differences in cell state proportions within major groups (ciliated, secretory, and basal-secretory) between control and IL-13-stimulated epithelia.

(F) Bar-plot depiction of data in (E).