Table 2. Different studies related to nanofibers .

Drug	Category	Result	References
Ofloxacin	Fluoroquinolone antibiotic	Article showed an accelerated effect on wound healing on superficial second degree burn in rats.	89
Silver sulfadiazine	Sulfonamides	The drug release was able to prevent the growth of a wide array of bacteria and accelerate the wound healing by preventing infection. Therefore it could accelerate the burn-wound closure rate.	90
Mupirocin	Antibiotic	The prepared PU/Mu composite scaffolds had satisfactory antibacterial activity especially against Staphylococcus aureus.	91
Acetaminophen	Analgesics and antipyretics	The developed NFs based layer can be applied either solely or in combination with other layers for desirable outcomes, for example, a multilayer dressing with this layer for burn pain management and other layer as antibiotics release for infection management.	92
Bromelain	Protein-digesting enzyme	Chitosan 2% w/v bromelain medicated textiles possesses great wound healing activity and could be considered as an effective natural topical burn wound healing treatment.	93
Gentamicin	Aminoglycoside antibiotic	The gentamicin released from the scaffolds showed a good inhibitory effect on the growth of bacteria and killed the microorganism. Thus, showing a great potential to be used as a wound healing material.	94
Mafenide Acetate	Sulfa antibiotic	Incorporation of mafenide acetate into chitosan/PVA nanofibers enhanced their antimicrobial activity against Pseudomonas aeruginosa and S. aureus.	95
Nitrofurazone	Nitrofuran class antibiotic	The prepared dual-layer nitrofurazone-loaded fiber dressings have satisfactory antibacterial activity against both gram-positive and gram-negative bacteria.	96
Centella asiatica, a medicinal herb	Effective against S. aureus, Escherichia coli, and P. aeruginosa	This article describes the diverse approaches that have been developed to produce electrospun nanofibres that are able to deliver naturally-derived chemical compounds in a controlled way and to prevent their degradation.	97
Silver acetate, silver tetrafluoroborate, silver nitrate, and silver phosphate	Antibacterial activity	The average diameters of the silver nanoparticles in gelatin nanofibers ranged between 13 and 25 nm, which was confirmed by transmission electron microscopy.	98
Calendula officinalis	Anti-inflammatory and antioedematous activities	This article indicated that C. officinalis extract is a suitable material for enhancing the biocompatibility of tissue engineering scaffolds.	99
Nisin	Antimicrobial drug	Novel nisin-loaded poly (vinyl alcohol)/wheat gluten/zirconia (Nisin-PVA/WG/ZrO2) nanofibrous membranes may have potential as a new nanofibrous membrane in drug delivery, wound dressing, and active food packaging.	100
Calendula officinalis	Anti-inflammatory and antioedematous activities	The results of in vivo experiments in rats suggested that HPGL– C. officinalis might be an interesting bioactive wound dressing material for clinical applications.	101
Ibuprofen	NSAIDs	Article demonstrated that scaffold properties are dependent on the environment in which they are placed and the importance of using serum, rather than saline, for initial in vitro evaluation of biofactor release from biodegradable scaffolds.	102
Silver sulfadiazine	Sulfonamides	Nanofibers with 0.6% silver sulfadiazine in zein, had shown excellent antibacterial activity for both gram-positive as well as gram-negative bacteria, so from this result we recommend 0.6% concentration of drug for further applications.	103
Asiaticoside	Antioxidant, anti-inflammatory, immunomodulatory	Its healing effect on deep partial-thickness burn injury of rats was obvious. Asiaticoside-loaded coaxial nanofibers provide a novel promising option for treatment of deep partial-thickness burn injury.	104
Silver sulfadiazine	Sulfonamides	The resultant nanofibers exhibited the appreciable antimicrobial activity against gram-negative E. coli and gram-positive Bacillus subtilis bacteria with considerable sustainability for repetitive use.	105
Mupirocin	Antibiotic	The fabricated nanofiber exhibited excellent hydrophilicity, cytocompatibility, sustained drug release, and antibacterial activity, which are favorable qualities for its use as a multifunctional material for wound dressing applications.	106
Ciprofloxacin	Antibiotic	Demonstrated promising wound resorption characteristics by using in vivo full-thickness excisional skin wound healing mice model.	107
Gabapentin and acetaminophen	Anticonvulsant and analgesics	The combination of quick release of strong nerve pain killer followed by slow release of mild pain killer reduced pain scores in a more professional manner with less side effects in burn patients.	108
Gentamicin	Antibiotic	The in vitro susceptibility tests confirmed that the gentamicin released from the liposomes immobilized at the surface of electrospun nanofiber matrix has bactericidal activity against E. coli, P. aeruginosa and S. aureus. The results showed that the developed system has promising performance for wound dressing applications, avoiding infections caused by these common pathogens.	109