Table 1.

miRNAs connecting COVID-19, lung cancer and inflammation.

miRNA	SARS-CoV-2 target	Role in Lung Cancer	Role in Inflammation
miR-15b	Differentially expressed in Hamster lungs after SARS-C0V-2 infection [284]	Promotes lung cancer growth and invasion [286]	Expression positively correlates with inflammation [210]
miR-21	Predicted to bind to human coronavirus RNA [268]	Oncogenic miRNA in lung cancer [269]	Regulator of inflammatory response [270]
miR-29 family	Has 11 binding sites on SARS-CoV-2 genome [263]	Tumor suppressor with role in therapy resistance [264,265]	Anti-inflammatory in cancer and other diseases [266,267]
miR-98	Targets TMPRSS2 in lung endothelial cells [281]	Inhibits lung cancer proliferation and metastasis [283]	Expression negatively correlates with inflammatory cytokines [282]
miR-195	Differentially expressed in Hamster lungs after SARS-C0V-2 infection [284]	Tumor suppressor that associates with improved survival [287]	Promotes resolution of inflammation [285]
miR-200 family	miR-200c is predicted to regulate ACE2 in respiratory cells [274]	Tumor suppressor and negative regulators of EMT [81,273]	Members of this family have been reported to be pro-inflammatory [275,276] as well as anti-inflammatory [277,278],
miR-421	Regulates ACE2 [279]	Overexpressed in lung cancer and associates with poor prognosis [280]	Aggravates inflammatory response in lung tissues [213]
miR-1207	Targeted directly by SARS-CoV-2 RNA [288]	Tumor suppressor with inhibitory effect on metastasis [289]	De-repression of its target CSF1 results in acute inflammatory response in COVID-19 [288]
miR-1307	Predicted to have highest affinity for SARS-CoV-2 genome among 1872 miRNAs [261]	Promotes lung cancer growth and proliferation [262]	Promotes inflammatory responses [214]

Numbers in parenthesis are corresponding citations. CSF1: Colony Stimulating Factor 1, EMT: Epithelial-to-Mesenchymal Transition.