Table 4.
Associations of baseline cortisol features with subsequent annual percent change FG stratified by diabetes status (Normal: N = 443, Impaired fasting glucose: N = 148 and Diabetes: N = 109).
| Predictor | Outcome: Avg. annual Δglucose |
||
|---|---|---|---|
| Model 0 coefficient (95 %CI) |
Model 1 coefficient (95 %CI |
||
| wake-up cortisol | Normal | 0.099(−0.71, 0.91) | 0.138 (−0.683, 0.958) |
| IFG | 0.12 (−1.305, 1.546) | 0.085 (−1.345, 1.516) | |
| Diabetes | −0.339 (−1.72, 1.042) | −0.289 (−1.674, 1.097) | |
| P-value for interaction | 0.8541 | 0.8714 | |
| CAR | Normal | −0.152 (−1.028, 0.724) | −0.127 (−1.005, 0.751) |
| IFG | 0.05 (−1.758, 1.858) | 0.151 (−1.666, 1.967) | |
| Diabetes | 0.045 (−2.257, 2.347) | 0.308(−2.029, 2.644) | |
| P-value for interaction | 0.9727 | 0.9203 | |
| Total AUC | Normal | −0.112(−1.217, 0.992) | −0.107(−1.229, 1.014) |
| IFG | 0.311 (−1.319, 1.941) | 0.188 (−1.46, 1.836) | |
| Diabetes | −0.603 (−2.499, 1.293) | −0.533 (−2.451, 1.385) | |
| P-value for interaction | 0.7712 | 0.8527 | |
| Overall decline slope | Normal | −2.226(−11.056, 6.604) | −2.607 (−11.48, 6.266) |
| IFG | 3.025 (−11.295, 17.345) | 2.52 (−11.89, 16.93) | |
| Diabetes | 19.897 (2.29, 37.5) | 19.21 (1.519, 36.908) | |
| P-value for interaction | 0.0879 | 0.0955 | |
| Bedtime cortisol | Normal | 0.017 (−0.642, 0.676) | −0.003 (−0.67, 0.66) |
| IFG | 0.247 (−0.777, 1.27) | 0.187 (−0.844, 1.218) | |
| Diabetes | 0.636 (−0.561, 1.833) | 0.651 (−0.549, 1.852) | |
| P-value for interaction | 0.6577 | 0.6365 | |
Model 0: adjust for age, sex, race/ethnicity.
Model 1: adjust for age, sex, race/ethnicity, physical activity, smoking, CES-D, BMI.
Interpretation = Betalog-cortisol feature × ln(1.01), β-coefficient interpretation: one percent increase in the cortisol features increases (or decreases) the Avg. annual Δglucose by (β/100) units.
Note: Bold values signifies p < 0.05.