Table 2.
Basic information of some key targets of DHJSD against osteoporosis.
| UniProt ID | Gene symbol | Protein names | Degree |
|---|---|---|---|
| P35354 | PTGS2 | Prostaglandin G/H synthase 2 | 144 |
| P03372 | ESR1 | Estrogen receptor | 98 |
| P0DP23 | CALM1 | Calmodulin-1 | 96 |
| P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | 96 |
| P10275 | AR | Androgen receptor | 85 |
| P35228 | NOS2 | Nitric oxide synthase, inducible | 80 |
| P23219 | PTGS1 | Prostaglandin G/H synthase 1 | 74 |
| Q15596 | NCOA2 | Nuclear receptor coactivator 2 | 70 |
| P24941 | CDK2 | Cyclin-dependent kinase 2 | 68 |
| P37231 | PPARG | Peroxisome proliferator-activated receptor gamma | 68 |
| P49841 | GSK3B | Glycogen synthase kinase-3 beta | 65 |
| Q92731 | ESR2 | Estrogen receptor beta | 62 |
| P20248 | CCNA2 | Cyclin-A2 | 59 |
| P27487 | DPP4 | Dipeptidyl peptidase 4 | 57 |
| P07550 | ADRB2 | Beta-2 adrenergic receptor | 52 |
| P19793 | RXRA | Retinoic acid receptor RXR-alpha | 52 |
| Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 51 |
| O14757 | CHEK1 | Serine/threonine-protein kinase Chk1 | 48 |
| P22303 | ACHE | Acetylcholinesterase | 34 |
| P08709 | F7 | Coagulation factor VII | 33 |
| Q15788 | NCOA1 | Nuclear receptor coactivator 1 | 25 |
| P35968 | KDR | Vascular endothelial growth factor receptor 2 | 24 |
| P25100 | ADRA1D | Alpha-1D adrenergic receptor | 15 |
| P06401 | PGR | Progesterone receptor | 15 |
| P31645 | SLC6A4 | Sodium-dependent serotonin transporter | 15 |
| P35372 | OPRM1 | Mu-type opioid receptor | 14 |
| P21728 | DRD1 | D (1A) dopamine receptor | 12 |
| P08235 | NR3C2 | Mineralocorticoid receptor | 12 |
| Q01959 | SLC6A3 | Sodium-dependent dopamine transporter | 12 |
| P27338 | MAOB | Amine oxidase [flavin-containing] B | 10 |
| Q92934 | BCL2 | Bcl2-associated agonist of cell death | 8 |
| P00918 | CA2 | Carbonic anhydrase 2 | 8 |
| P42574 | CASP3 | Caspase-3 | 8 |
| Q04206 | RELA | Transcription factor p65 | 7 |
| P31749 | AKT1 | RAC-alpha serine/threonine-protein kinase | 6 |
| Q07812 | BAX | Apoptosis regulator BAX | 6 |
| P05412 | JUN | Transcription factor AP-1 | 6 |
| O95150 | TNFSF15 | Tumor necrosis factor ligand superfamily member 15 | 5 |
| P55211 | CASP9 | Caspase-9 | 4 |
| P24385 | CCND1 | G1/S-specific cyclin-D1 | 4 |
| P03956 | MMP1 | Interstitial collagenase | 4 |
| P08588 | ADRB1 | Beta-1 adrenergic receptor | 3 |
| P35869 | AHR | Aryl hydrocarbon receptor | 3 |
| P15121 | AKR1B1 | Aldo-keto reductase family 1 member B1 | 3 |
| Q14790 | CASP8 | Caspase-8 | 3 |
| P06493 | CDK1 | Cyclin-dependent kinase 1 | 3 |
| P05177 | CYP1A2 | Cytochrome P450 1A2 | 3 |
| P08684 | CYP3A4 | Cytochrome P450 3A4 | 3 |
| P09211 | GSTP1 | Glutathione S-transferase P | 3 |
| Q92819 | HAS2 | Hyaluronan synthase 2 | 3 |
| P09601 | HMOX1 | Heme oxygenase 1 | 3 |
| P05231 | IL6 | Interleukin-6 | 3 |
| P28482 | MAPK1 | Mitogen-activated protein kinase 1 | 3 |
| P04150 | NR3C1 | Glucocorticoid receptor | 3 |
| Q03181 | PPARD | Peroxisome proliferator-activated receptor delta | 3 |
| P14672 | SLC2A4 | Solute carrier family 2, facilitated glucose transporter member 4 | 3 |
| P00441 | SOD1 | Superoxide dismutase [Cu-Zn] | 3 |
| Q9H3D4 | TP63 | Tumor protein 63 | 3 |
| P15692 | VEGFA | Vascular endothelial growth factor A | 3 |
| Q13085 | ACACA | Acetyl-CoA carboxylase 1 | 2 |
| P00533 | EGFR | Epidermal growth factor receptor | 2 |
| P01106 | MYC | Myc proto-oncogene protein | 2 |
| P02768 | ALB | Albumin | 1 |
| P01133 | EGF | Pro-epidermal growth factor | 1 |
| P27361 | MAPK3 | Mitogen-activated protein kinase 3 | 1 |