Table 4.

Haplotype analysis of LOX, ALDH3A1, and SPARC genes in Korean keratoconus patients

Gene	Haplotype	Case	Control	Chi-square	p-value
LOX	rs2956540-rs2288393
	LOX_H1 : C-G	0.762	0.693	3.999	0.046
	LOX_H2 : G-C	0.133	0.158	0.838	0.360
	LOX_H3 : G-G	0.101	0.148	3.597	0.058
ALDH3A1	rs60610024-rs2228100-rs57555435
	ALDH3A1_H1 : C-C-G	0.569	0.477	5.33	0.021
	ALDH3A1_H2 : C-G-G	0.303	0.441	13.187	<0.001
	ALDH3A1_H3 : A-C-T	0.089	0.055	2.633	0.105
	ALDH3A1_H4 : A-C-G	0.031	0.026	0.144	0.704
	IVS3-62 a>g - rs116962241
	ALDH3A1_H5 : G-A	0.9	0.945	3.922	0.048
	ALDH3A1_H6 : A-C	0.089	0.05	3.27	0.071
SPARC	EX10+212G>A_EX10+58C>G
	SPARC H1 : C-C	0.651	0.654	0.003	0.959
	SPARC H2 : G-T	0.349	0.346	0.003	0.959
	IVS4-234a>c_IVS4+153g>c
	SPARC H3 : C-G	0.904	0.926	0.499	0.479
	SPARC H14 : G-C	0.077	0.074	0.013	0.908
	IVS4+127a>g_IVS4+31c>t_IVS3+42t> c_IVS3+36t>g_EX3+9A>G
	SPARC H5 : A-C-T-T-A	0.512	0.506	0.01	0.919
	SPARC H6 : G-T-T-G-A	0.359	0.327	0.369	0.544
	SPARC H7 : G-T-C-T-G	0.088	0.093	0.019	0.889
	SPARC H8 : G-T-T-T-A	0.035	0.074	2.433	0.119

LOX = lysyl oxidase; ALDH3A1 = aldehyde dehydrogenase 3A1; SPARC = secretory protein acidic and rich in cysteine.