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Barcelona Clinic Liver Cancer (BCLC) staging and treatment strategy. Modified from Forner et al. [8] with permission from Elsevier. HCC, hepatocellular carcinoma; ECOG, Eastern Cooperative Oncology Group; PS, performance status; BSC, best supportive care. *Currently, sorafenib followed by regorafenib has been shown to be effective. Lenvatinib has been shown to be non-inferior to sorafenib, but no second-line option after Lenvatinib has been explored.
