Table 1.
Baseline clinical characteristics of SNV patients with stroke and those without stroke.
| Total, n=2644 | Patients with stroke, n=159 | Patients without stroke, n=2485 | p-value | |
|---|---|---|---|---|
| Age at diagnosis (years) | 56.65 ± 16.84 | 66.50 ± 13.34 | 56.02 ± 16.85 | <0.001 |
| ≤54 | 1052 (39.8) | 28 (17.6) | 1024 (41.2) | <0.001 |
| 55-74 | 1225 (46.3) | 84 (52.8) | 1141 (45.9) | |
| ≥75 | 367 (13.9) | 47 (29.6) | 320 (12.9) | |
| Sex, n (%) | 0.885 | |||
| Male | 1191 (45.1) | 73 (45.9) | 1118 (45.0) | |
| Female | 1453 (54.9) | 86 (54.1) | 1367 (55.0) | |
| Diagnosis [ICD-10 code], n (%) | <0.001 | |||
| MPA (M31.7) | 904 (34.2) | 79 (49.7) | 825 (33.2) | |
| GPA (M31.3) | 606 (22.9) | 31 (19.5) | 575 (23.1) | |
| EGPA (M30.1) | 593 (22.4) | 32 (20.1) | 561 (22.6) | |
| PAN (M30.0) | 541 (20.5) | 17 (10.7) | 524 (21.1) | |
| Geographic Area, n (%) | 0.219 | |||
| Seoul | 1197 (45.3) | 64 (40.3) | 1133 (45.6) | |
| Outside Seoul | 1447 (54.7) | 95 (59.7) | 1352 (54.4) | |
| Comorbidities [ICD-10 code] | ||||
| Hypertension [I10-15] | <0.001 | |||
| No | 1477 (55.9) | 60 (37.7) | 1417 (57.0) | |
| Yes | 1167 (44.1) | 99 (62.3) | 1068 (43.0) | |
| Diabetes mellitus [E10-14] | <0.001 | |||
| No | 1813 (68.6) | 87 (54.7) | 1726 (69.5) | |
| Yes | 831 (31.4) | 72 (45.3) | 759 (30.5) | |
| Atrial fibrillation/flutter [I48] | 0.299 | |||
| No | 2576 (97.4) | 153 (96.2) | 2423 (97.5) | |
| Yes | 68 (2.6) | 6 (3.8) | 62 (2.5) | |
| Dyslipidemia [E78] | 0.005 | |||
| No | 1409 (53.3) | 67 (42.1) | 1342 (54.0) | |
| Yes | 1235 (46.7) | 92 (57.9) | 1143 (46.0) | |
| Medication usage, n (%) | ||||
| Immunosuppressive agents | ||||
| Glucocorticoid usage ≥ 1 year |
1225 (46.3) | 31 (19.5) | 1194 (48.1) | <0.001 |
| Cyclophosphamide | 1124 (42.5) | 62 (39.0) | 1062 (42.7) | 0.399 |
| Rituximab | 252 (9.5) | 8 (5.0) | 244 (9.8) | 0.064 |
| Azathioprine/mizoribine | 991 (37.5) | 29 (18.2) | 962 (38.7) | <0.001 |
| Methotrexate | 431 (16.3) | 8 (5.0) | 423 (17.0) | <0.001 |
| Antiplatelet agents | ||||
| Aspirin | 608 (23.0) | 32 (20.1) | 576 (23.2) | 0.430 |
| Clopidogrel | 232 (8.8) | 10 (6.3) | 222 (8.9) | 0.318 |
| Statins | 996 (37.7) | 45 (28.3) | 951 (38.3) | 0.015 |
Values are expressed as mean (standard deviation) or number (percentages).
SNV, systemic necrotizing vasculitis; ICD, International classification of diseases; MPA, microscopic polyangiitis; GPA, granulomatosis with polyangiitis; EGPA, eosinophilic granulomatosis with polyangiitis; PAN, polyarteritis nodosa.