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. 2021 Mar 31;11:657094. doi: 10.3389/fonc.2021.657094

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Copyright © 2021 Li, Li, Wang, Liang, Luo, Han, Li, Chen, Zhang, Liu, Wang, Chen, Wang, Zhao and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LINC01977 knockdown reduced breast cancer cell proliferation, metastasis, and chemoresistance to DOX. (A) The efficiency of shRNA knockdown was evaluated by real-time PCR in MDA-MB-231 and MCF-7 cells. (B) MTT assay was used to evaluate cell viability of MDA-MB-231 and MCF-7 transfected by control or knockdown plasmids. (C) Colony formation assay displayed the influence of LINC01977 knockdown on breast cancer cell proliferation. (D) IC50 value for DOX in MDA-MB-231 and MCF-7 transfected by control or knockdown plasmids. (E) Cytotoxicity assay was used to test the suppression of DOX resistance caused by LINC01977 knockdown in MDA-MB-231 and MCF-7 cells. DOX concentration: 0.1μM in MDA-MB-231 and 0.5μM in MCF-7 cells. (F) Cell migration and invasion assays. (G) Wound healing assay. (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001; Student’s t-test).