Table 2:

Mean (standard error) percent changes from baseline in body mass index at years 1, 4, and the time of cognitive assessment and changes in fitness at years 1 and 3, by FI tertile. Mixed effects models were used to summarize overall differences across the three time points. Percent change in body mass index is calculated from the current difference from baseline divided by the baseline value.

	Year 1	Year 4	Time of Cognitive Assessment	Mean Difference Over Time p-value
BMI Percent Change
Overall Mean (SE)
DSE	−0.72 (0.18)	−0.70 (0.18)	−1.43 (0.18)
ILI	−8.92 (0.18)	−4.27 (0.18)	−4.11 (0.18)
Difference (DSE-ILI) [95% CI]
Overall	8.21 [7.72,8.70]	3.57 [3.08,4.06]	2.68 [2.20,3.17]	<0.01
First textile	8.78 [8.01,9.55]	3.90 [3.13,4.67]	3.47 [2.70, 4.26]	<0.01
Second textile	8.28 [7.44,9.11]	3.93 [3.09,4.76]	2.23 [1.40, 3.07]	<0.01
Third tertile	7.49 [6.54,8.43]	2.82 [1.88,3.77]	2.30 [1.36, 3.25]	<0.01
Fitness Change (METS)			Not Measured
Overall Mean (SE)
DSE	6.52 (0.64)	0.13 (0.65)
ILI	21.74 (0.63)	5.69 (0.64)
Difference (DSE-ILI) [95% CI]
Overall	−15.22 [−16.98,−13.46]	−5.56 [−7.35,−3.77]		<0.01
First tertile	−17.32 [−20.23,−14.40]	−6.65 [−9.60,−3.71]		<0.01
Second tertile	−14.42 [−17.51,−11.33]	−5.94 [−9.09,−2.79]		<0.01
Third tertile	−13.64 [−16.82,−10.45]	−4.05 [−7.29,−0.80]		<0.01