. Author manuscript; available in PMC: 2022 May 1.

Published in final edited form as: J Comput Neurosci. 2021 Feb 17;49(2):107–127. doi: 10.1007/s10827-021-00780-x

Table 1:

Summary of key results of two computational models and the associated experimental support.

Condition	Computer modeling results		Experimental support
Condition	phenomenological model	mean field model	Experimental support
model description	Eqs. 1–6, Fig. 1D, Table 2	Eqs. 8–14, Fig. 2B, Table 3	n/a
evoked pain	Figs. 4A–C, Fig. 5A	Fig. 6A–C	Fig. 3C,D, rat ACC and S1 LFP data reported in (Xiao et al., 2019)
non-evoked pain	Figs. 4D,E, Fig. 5B	Fig. 6D	Fig. 3B,C,D, rat ACC and S1 LFP data reported in (Xiao et al., 2019)
chronic pain	n/a	Fig. 7B,C,H, Fig. 7A,D–H, Fig. 8A–C	pain aversion in rat ACC neurons (Zhang et al., 2017) Fig. 3E,F, rat S1→ACC projection (Singh et al., 2020)
placebo & nocebo	n/a	Fig. 8D,E	none found
stimulus prediction	n/a	Fig. 9A–C	human S1 activity (Gross et al., 2007; Zhang et al., 2012)
pain anticipation	n/a	Fig. 10A Fig. 10B,C	rat’s behavior (Urien et al., 2018) rat ACC activity (Urien et al., 2018)