Table 2.

Multivariate analysis of Time to Treatment Failure with PD-1 monotherapy

		HR	[95% CI]	p-value
Log10(TMB)		0.41	[0.25 – 0.67]	<.001
Driver Class	NRAS Q61	1.38	[0.83 – 2.29]	0.20	<.001
	NF1	1.04	[0.54 – 1.99]	>0.9
	Other/Unknown	0.35	[0.18 – 0.67]	0.002
	BRAF V600	REF
ECOG Performance Status	2–3	4.98	[2.29 – 10.8]	<.001	0.001
	1	1.33	[0.86 – 2.04]	0.20
	0	REF
Stage	M1d	1.90	[1.09 – 3.33]	0.025	<.001
	M1c	0.97	[0.57 – 1.64]	0.90
	M1b	0.46	[0.27 – 0.81]	0.007
	M0-M1a	REF

ECOG, Eastern Cooperative Oncology Group.