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. 2021 Apr 14;11:8183. doi: 10.1038/s41598-021-87791-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Evaluation of cGMP dependent pathway using guanylate cyclase inhibitor, ODQ (20 μM), in TGFβ1 (10 ng/mL) stimulated keratocyted. Addition of ODQ eliminated the anti-myofibroblastic effect of NO donors (DETA NONOates and sodium nitrite) as demonstrated by the restored α-SMA expression. Statistical significance was determined using one-way ANOVA followed by the Bonferroni multiple comparison test and the significant difference compared to no treated control (*p < 0.05, **p < 0.01); ^#significant difference compared to TGFβ1 treated group (^#p < 0.05).