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. 2021 Apr 14;4:370. doi: 10.1038/s42003-021-01897-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a SPRING plot of the 15 human clusters identified in 12 NSCLCs. Each point represents one cell. Each color represents a defined transcriptomic cluster. b Epithelial cells (green); c immune cells (panel legend defines subpopulations); d endothelial cells (maroon), and e fibroblasts (blue) were identified. f SPRING plots of the 15 clusters in ten ADC patients (eight carrying KRAS mutations, two wildtypes for KRAS). Dotted squares highlight cluster 10 (C10) is unique to the KRAS-mutant samples.