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. 2021 Apr 14;4:370. doi: 10.1038/s42003-021-01897-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a A549 xenografts tumor volumes at treatment termination (vehicle n = 20, red; PTC596 n = 15, blue; PTC208 n = 7, black) normalized to the tumor volume measured at the beginning of treatment. The difference in tumor size at day 21 was statistically significant (p values are indicated). b SPRING plots showing epithelial compartments (green) in vehicle- (n = 3, left panels) versus PTC596-treated tumors (n = 2, right panels). c Pie charts summarizing the epithelial cell proportions in vehicle- (left panels) and PTC596-treated tumors (right panels). d SPRING plots of the 13 clusters in vehicle- (left panel) and PTC596- (right panel) treated tumor samples. e Pie charts summarizing epithelial sub-cluster compositions in vehicle- (left panels) and PTC596- (right panels) treated tumors. f The graph shows the percentage of change in tumor volume measured by MRI at the indicated time points, between PTC596 (n = 7, blue) and vehicle-treated (n = 8, red) groups. Error bars represent SD. P value is indicated.