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. 2021 Apr 14;12:2244. doi: 10.1038/s41467-021-22471-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Heatmaps representing relative lipid abundance in ACSL1-deficient (ACSL1 KO L1, L2) or overexpressing (ACSL1 OE) BT-549 cells as fold-change in mole percent compared to control cells after 16 h treatment with 50 μM αESA (right and middle) or in untreated cells (left). The rightmost heatmap shows only the subset of lipids with 18:3 acyl chains. Yellow indicates an increase in relative abundance and blue shows a decrease in relative abundance. PL = phospholipids, CE = cholesterol esters, Cer = ceramide, DAG = diacylglycerol, PC O- = ether-linked phosphatidylcholine, PE O- = ether-linked phosphatidylethanolamine, SM = sphingomyelin, TAG = triacylglycerol. Source data are provided as a Source Data file.