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. 2021 Apr 14;11:220. doi: 10.1038/s41398-021-01337-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Adult male Long-Evans rats were intermittently and randomly exposed to ethanol vapor (CIE, n = 18) or Air (AIR, n = 18) for 8 weeks. a The blood ethanol concentrations (BECs) were randomly collected from 11 of 18 CIE rats and measured once per week. b The body weight of rats during 8-week CIE or Air exposure (n = 11/group). c The physical withdrawal scores of CIE and AIR rats at 4, 8, 12, and 24 h abstinence after 8-week vapor exposure (n = 18/group). d, e The average paw withdrawal threshold or latency of rats before and after 8-week chronic vapor exposure (CIE n = 18, AIR n = 15). All data are expressed as mean ± SEM. ***p < 0.001, ^^^p < 0.001, ¤¤¤p < 0.001 vs. Air group, ###p < 0.001 vs 8–24 h withdrawal time within CIE group by two-way RM ANOVA.