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. 2021 Apr 14;11:220. doi: 10.1038/s41398-021-01337-3

Fig. 3. Inhibiting LHb MAGL or FAAH or activating CB1R has an analgesic effect in both CIE and air-exposed rats.

Fig. 3

Adult male Long-Evans rats underwent CIE or air exposure for 8 weeks. At 24 h abstinence from the last vapor exposure, these rats randomly received bilateral intra-LHb infusion of JZL184 (MAGL inhibitor, n = 13 rats/ group), URB597 (FAAH inhibitor, n = 14 rats/group), or WIN 55,212-2 (CB1R agonist, n = 14 rats/group) alone or combined with rimonabant (RIM, an inverse CB1R agonist) 30 min before the behavioral test. The bar graphs summarize the effect of these compounds on the paw withdrawal threshold (PWT, a, c, and e) or latency (PWL, b, d, and f) in all subjects tested. All data are expressed as mean ± SEM. ###p < 0.001 vs vehicle or Air group; *p < 0.05, **p < 0.01, ***p < 0.001 vs vehicle, JZL + RIM or RIM within each vapor group, revealed by two-way RM ANOVA followed by Bonferroni post-hoc test.