. Author manuscript; available in PMC: 2021 Aug 11.

Published in final edited form as: Mult Scler. 2020 Oct 15;27(9):1384–1390. doi: 10.1177/1352458520964409

Table 2:

Sample size calculations using OCT outcome measures in progressive MS (total number of patients to randomize assuming 80% power to detect the specified effect size)

		Effect size
		50%	60%	70%	80%
Outcome measure	pRNFL	>9500	7336	5490	4050
	MV - Cirrus	1950	1370	1054	852
	MV - Spectralis	270	204	172	140
	GCIP (every 6 month measurements)	386	264	196	152
	GCIP (yearly measurements)	490	350	254	198