Table 1.

Clinical trials with completed or recruiting status with probiotic, prebiotics, and FMT interventions for T1D prevention or therapy.

Clinical Trial identifiera	Status	Study population	Intervention	Sponsor
Probiotics
NCT03961854	Recruiting	T1D <1 Year; 8–17 years	Drug: L. johnsonii N6.2 Probiotic Drug: Placebo Capsule	University of Florida
NCT03961347	Recruiting	T1D <3 Years; 18–45 years	Drug: L. johnsonii N6.2 Probiotic Drug: Placebo Capsule	University of Florida
NCT03423589	Completedb	Full sibling of someone with T1D; 6–17 years	Dietary Supplement: VSL#3	Medical College of Wisconsin
NCT04141761	Recruiting	T1D <90 days; 6–17 years	Dietary Supplement: Visbiome (VSL#3) Other: Placebo	Medical College of Wisconsin
NCT03880760	Recruiting	T1D diagnosis; 6–18 years	Other: L. johnsonii MH-68, B. animalis subsp. lactis CP-9 and L. salivarius AP-32 Other: Placebo	China Medical University Hospital
Prebiotics
NCT02442544	Active, not recruiting	T1D >1 year; 8–17 years	Dietary Supplement: Prebiotic (1:1 oligofructose: inulin) Dietary Supplement: Placebo	Alberta Children's Hospital
NCT04114357	Not yet recruiting	T1D >4 mos., <24 mos.; 12–16 years	Drug: Acetylated and Butyrylated High Amylose Maize Starch	Indiana University
NCT02903615	Active, not recruiting	T1D diagnosis; 18–70 years	Other: Novel diet (lower carbohydrate, Mediterranean-style, prebiotic fiber focus) Other: Standard diet (Standard diabetes diet recommendations)	Garvan Institute of Medical Research
ACTRN12618001391268	Completedb	T1D >6 months; 18–45 years	Dietary Supplement: Acetylated and Butyrylated High Amylose Maize Starch	Monash University
Fecal transplant
NCT04124211	Recruiting	T1D diagnosis; 18–65 years	Biological: Fecal Microbiota Transplantation (FMT)	The Third Affiliated Hospital of Southern Medical University
NL3542	Completed (41)	T1D <6 weeks; 18–30 years	Biological: Fecal Microbiota Transplantation (FMT)	University of Amsterdam

^*Data from 08/09/2020.

^aIdentifiers starting with NCT were collected from clinicaltrials.gov; Identifier starting with ACTRN was collected from the Australia New Zealand Clinical Trials Registry and starting with NL from the Netherlands Trial Register.

^bNo results reported.