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. 2021 Apr 1;8:645651. doi: 10.3389/fmed.2021.645651

Table 3.

Treatments and outcomes in symptomatic and asymptomatic COVID-19 cases.

Symptomatic COVID-19 Asymptomatic COVID-19
Items With pneumonia Without pneumonia With pneumonia Without pneumonia p-value
(n = 430) (n = 31) (n = 23) (n = 14)
Treatments
   Antiviral therapy 420 (97.7) 31 (100) 23 (100) 13 (92.9) 0.865
   Abidol 200 (46.5) 16 (51.6) 14 (60.9) 6 (42.9) 0.543
   Lopinavir/ritonavir 310 (72.1) 24 (77.4) 10 (43.5)* 8 (57.1) 0.022
   Interferon 259 (60.2) 24 (77.4) 14 (60.9) 8 (57.1) 0.295
   Ribavirin 44 (10.2) 2 (6.5) 2 (8.7) 1 (7.1) 0.876
   Chloroquine phosphate 53 (12.3) 2 (6.5) 4 (17.4) 2 (14.3) 0.635
   Antibiotic therapy 233 (54.2)* 11 (35.5) 7 (30.4)* 3 (21.4)* 0.004
   Administration of corticosteroids 124 (28.8)* 2 (6.5)* 0 (0)* 0 (0)* <0.001
   Non-invasive mechanical ventilation 18 (4.2) 0 (0) 0 (0) 0 (0) 0.121
   Invasive mechanical ventilation 11 (2.6) 0 (0) 0 (0) 0 (0) 0.229
   ECMO 7 (1.6) 0 (0) 0 (0) 0 (0) 0.339
   CRRT 9 (2.1) 0 (0) 0 (0) 0 (0) 0.278
Clinical outcomes
   Severe cases 61 (14.2)* 3 (9.7) 0 (0) 0 (0) 0.011
   Critical cases (admission to ICU) 46 (10.7)* 1 (3.2) 0 (0) 0 (0) 0.019
   ARDS 18 (4.2) 0 (0) 0 (0) 0 (0) 0.121
Death 3 (0.7) 0 0 0 0.533
Duration of viral shedding, days 14.0 (9.0–21.0) 15.0 (8.8–23.8) 13.0 (7.0–19.0) 13.0 (8.3–17.8) 0.524
Duration of hospitalization, days 16.0 (11.5–24.0) 16.0 (10.0–23.0) 16.0 (11.0–22.0) 12.0 (8.8–17.0)* 0.234

Values are presented as median (IQR) or number (percentage).

*

p < 0.05 compared with other groups combined; p-values were compared by Kruskal–Wallis test, χ2 test, Fisher exact test, or one-way analysis of variance.

ECMO, extracorporeal membrane oxygenation; CRRT, continuous renal replacement therapy; ARDS, acute respiratory distress syndrome; ICU, intensive care unit.