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. 2021 Apr 14;11:8177. doi: 10.1038/s41598-021-87759-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Identification of significantly-altered molecular pathways in SIRT1-depleted adipocytes. Prediction of significantly-affected molecular pathways by “WikiPathways” analysis (a) or MSigDB Hallmark gene-sets (b) in SIRT1-depleted adipocytes. Annotations from WikiPathways analysis or MSigDB Hallmark gene-sets were used for functional enrichment analysis among differentially expressed proteins (P < 0.05). Significantly enriched pathways (P < 0.05) were used for plotting. Axes show p-value of overlap and highlighted in red and blue are the up-regulated and down-regulated protein sets, respectively.