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. 2021 Apr 14;11:8177. doi: 10.1038/s41598-021-87759-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Identification of significantly-affected transcription factors and target mapping in SIRT1-depleted adipocytes. Heatmap clustering of the most significantly-affected molecules mapped to their upstream regulators in SIRT1-depleted adipocytes. Red and blue indicate up- and down-regulated molecules, respectively. Shown are upstream regulators with a downstream target overlap of P < 10^–5 and an IPA activation z score > 2.7 or < − 2.7. The activation z score was calculated by IPA and it predicted if a pathway was activated or inhibited based on the directional change in proteins included in the quantified pathways.