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. 2021 Apr 14;11:8177. doi: 10.1038/s41598-021-87759-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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SIRT1-dependence of SREBF1c and PPARα signaling in 3T3-L1 adipocytes. (a) Quantitative analysis of the expression levels of SREBF1c and its downstream transcriptional targets in ShScrambled or SIRT1-depleted (ShSIRT1) adipocytes at Day 6 post-differentiation. (b) Quantitative analysis of the expression levels of PPARα and its downstream transcriptional targets in ShScrambled or SIRT1-depleted (ShSIRT1) adipocytes at Day 6 post-differentiation. Boxed region indicates the time-point at which PPARα protein levels were quantified. In (a,b), qPCR and western blot data were from 4 and 3 independent experiments, respectively. Statistical analysis of the dataset was performed using a Student’s t test (*P < 0.05; ****P < 0.0001; n.s. not significant).