Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Apr 14;11:8173. doi: 10.1038/s41598-021-87696-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Inhibition of TRPV4 by ginkgetin abrogates oxLDL-induced macrophage foam cell formation. (A) Thioglycolate-induced murine peritoneal macrophages were treated overnight with 50 µg/ml oxLDL, followed by a 3 h preincubation with vehicle or 1 or 10 µM ginkgetin. Cells were treated with 50 µg/mL native LDL (nLDL) as control. Original magnification: 40x. (B) Quantification of the results shown in (A). n = 500 cells/condition. Student’s t-test; ***p < 0.001. Data represent ± SEM. (C) TRPV4 KO RPMs were transduced with either Ade-Vec or Ade-TRPV4, and were untreated or treated with GGT in the presence of oxLDL for 16 h on day 5 of transduction for macrophage foam cell formation. (D) Quantification of the results shown in C. n = 100 cells/condition. Student’s t-test; ***p < 0.001.