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Number of patients harboring somatic gene alterations according to endocrine responsiveness.
| Primary resistance (n = 7) | Secondary resistance (n = 8) | Responsive (n = 9) | P value | |
|---|---|---|---|---|
| TP53 | 5 (71%) | 1 (13%) | 1 (11%) | 0.014* |
| PIK3CA | 3 (43%) | 1 (13%) | 3 (33%) | 0.41 |
| AKT1 | 0 | 2 (25%) | 4 (44%) | 0.13 |
| ESR1 | 2 (29%) | 3 (38%) | 1 (11%) | 0.44 |
| MYC | 1 (14%) | 2 (25%) | 0 | 0.29 |
*P < 0.05 is considered significant.
