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. 2021 Apr 14;11:8112. doi: 10.1038/s41598-021-86821-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The difference of gene expression patterns in cardiomyocytes with high and low Nppa expression. (a) Hierarchical clustering of both genes and samples based on their gene expression profiles in the gene expression matrix. Cardiomyocytes were divided into two subgroups based on Nppa expression level; high-Nppa group and low-Nppa group. The average gene expression levels were calculated for samples from each time point in the high-Nppa group and low-Nppa group. (b) Bar graph shows the number of DEGs detected in high-Nppa, low-Nppa and common group, compared with sham group. “Common genes” indicate DEGs present in both high-Nppa expressing cardiomyocytes and low-Nppa expressing cardiomyocytes.