Table 2.

Summary of modalities through which RBCs contribute to hemostasis.

• Effect upon humoral and endothelial mechano-signaling via altered blood flow

• RBC membrane surface as physical interface with other hemostatic elements

• RBC membrane surface as biochemical/signaling trigger and accelerant in coagulation cascade

• Direct signaling via exported biomolecules from RBCs to endothelial cells and platelets

• Elaboration of RBC microparticles, with both mechanical and signaling effects

• Contribution of intact RBCs to 3D geometry and biophysical properties of thrombi