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. 2021 Apr 1;12:619761. doi: 10.3389/fimmu.2021.619761

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Copyright © 2021 He, Fu, Zhou, Su, Gao, Zhang, Huang, Du and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CPT treatment alleviates the weight loss and behavioral disorder of LPS-injected PD mouse model. (A) Experiment procedure. Mice were injected with LPS (5 μg/μL, 2μL) or equal volume PBS into the right SNpc after anesthesia and treated every two days with CPT (1 mg/kg) for 3 days before surgery and for a total of 24 days. (B) The weight change of mice during the experiment. Before the operation and on the 28th day after the operation, the body weight of mice was measured. (C-E) The locomotor activity of mice was tested using the open field assay. Results are shown as means ± SD (n= 5). ^##p < 0.01 vs. the no-treatment (NT) group; **p < 0.01 vs. the LPS-injected group.