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. 2021 Apr 1;12:619761. doi: 10.3389/fimmu.2021.619761

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Copyright © 2021 He, Fu, Zhou, Su, Gao, Zhang, Huang, Du and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CPT treatment inhibits inflammatory response and regulates microglia polarization in LPS- injected PD mice. On the 28th day after modeling, the midbrain of mice was peeled off and ground. (A–E) AKT/Nrf2/HO-1 and NF-κB signal pathways were detected using western blot. (F–L) The mRNA levels of M1 markers (IL-6, COX-2, iNOS, and TNF-α) and M2 markers (Ym-1, CD206, and Arg-1) were detected using RT-PCR. Results are shown as means ± SD (n= 5).^##p < 0.01 vs. the no-treatment (NT) group; **p < 0.01 vs. the LPS-exposed group. ^##p < 0.01 vs. the no-treatment (NT) group corrected to ^#P < 0.05 and ^##P < 0.01 vs. the no-treatment (NT) group.