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. 2021 Apr 1;12:649962. doi: 10.3389/fmicb.2021.649962

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Copyright © 2021 Li, Sang, Jiang, Wei, Shen, Huang, Li and Ni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The deletion mutant of candicidins in Streptomyces sp. GF20 had weaker antifungal activities against Xylaria sp. and M. anisopliae. (A) HPLC profiles of the metabolites of wide type Streptomyces sp. GF20 and mutant GF20 ΔfscA. The asterisk symbols (*) denote homologs of candicidin. (B,C), paired challenge assays of GF20 and the deletion mutant (GF20 ΔfscA) against Xylaria sp. (Xa, B) and M. anisopliae (Ma, C). (D) HRMS spectrum of compound 5 from GF20. (E) The predicted structure of candicidin D (5).