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. 2021 Apr 1;12:624561. doi: 10.3389/fgene.2021.624561

FIGURE 3.

FIGURE 3

F0 HDM exposure enhances severity to HDM induced airway hyperresponsiveness and cell count in BAL in F2 and F3. (A) F2 Resistance at 30 mg/ml of Mch is shown. F2 progeny from HDM-challenged mice exhibited increased AHR compared to those exposed to PBS. This was further enhanced by maternal HDM exposure. (B) F3 Resistance at 30 mg/ml of Mch is shown. F3 progeny from HDM-challenged mice exhibited increased AHR compared to those exposed to PBS. This was further enhanced by maternal HDM exposure. (C) F2 progeny from HDM-challenged mice exhibited increased BAL cell number compared to those exposed to saline. This was further enhanced by maternal HDM exposure. (D) F2 progeny from HDM-challenged mice exhibited increased BAL cell number compared to those exposed to PBS. This was further enhanced by maternal HDM exposure. Mean with SEM shown. P values derived from Ordinary One-Way ANOVA with multiple comparisons. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.