Figure 3.

S-acylated proteins in Fcγ receptor signaling and actin dynamics. Binding of IgG to the FcγR leads to localized clustering and signal transduction. Phosphorylation of the ITAM motifs and SFKs generates binding sites for Syk and the recruitment of LAT which together amplify the signal intensity. Additional downstream signaling leads to GTP-loading of both Cdc42 and Rac1 that results in Wiskott–Aldrich syndrome protein (WASP) and WASP-family verprolin homologous protein (WAVE) complex mediated actin rearrangements to drive particle engulfment. Two phosphatases, SHP and SHIP, serve as negative regulators of phagocytosis and are recruited by binding the inhibitor FcγRIIb and may also require S-acylation for their activity. Inset: All SFKs are myristoylated and most are S-acylated.